Showing posts with label offers. Show all posts
Showing posts with label offers. Show all posts

Monday, June 13, 2011

Targeted testing offers treatment hope for ovarian cancer patients

ScienceDaily (May 31, 2011) — Women with ovarian cancer could be helped by a new test that identifies the specific type of tumour they have, a conference will hear this week.

See Also:Health & MedicineOvarian CancerDiseases and ConditionsPersonalized MedicineBreast CancerLung CancerLeukemiaReferenceHysterectomyMetastasisOvarian cancerMenopause

Researchers at the University of Edinburgh hope this improved diagnosis will help doctors to personalise treatment programmes so that patients receive the most effective drugs.

The Edinburgh team worked with scientists from Ireland to identify six subgroups of the disease, each of which had a different genetic signature.

To do this, they analysed tissue samples from more than 350 ovarian cancer patients and compared this information with the patients' medical records.

The results show how genetic profiling of ovarian cancers might predict a person's response to drug treatments.

Researchers say the development may be particularly helpful for women with an aggressive form of ovarian cancer, which is typically caught late by current diagnostic tests.

This type of aggressive -- or 'high grade' -- cancer can respond well to a recently-developed drug that targets the blood supply of the cancer cells.

The team hopes that by identifying the women with this type of cancer at the earliest opportunity, they could use the drug more effectively and help to improve survival rates.

The findings will be presented at the American Society of Clinical Oncology (ASCO) conference, being held in Chicago this week.

Dr Charlie Gourley of the University of Edinburgh, who led the study, said: "This research shows that by conducting a detailed analysis of the genes of ovarian cancers we may be able to identify those patients who will respond well to new drug treatments. This could bring valuable improvements in survival rates for the disease and would help us to personalise a patient's care to ensure the greatest possible success."

Ovarian cancer is the fifth most common cancer in women, with around 6,800 women being diagnosed every year in the UK.

Of these, nearly two-thirds will not live beyond five years of their diagnosis.

Chemotherapy and surgery can be effective treatments, but women could have a greater chance of surviving the disease if it is identified earlier on.

The findings will be presented at ASCO on the 4th of June.

Email or share this story:

Sunday, June 12, 2011

Facelift incision offers safe option for some thyroid patients

ScienceDaily (May 31, 2011) — A facelift incision and robotics can help surgeons safely remove a portion of a diseased thyroid from some patients without the characteristic neck scar.

See Also:Health & MedicineThyroid DiseaseHormone DisordersToday's HealthcareMatter & EnergyMedical TechnologyRobotics ResearchEngineeringStrange ScienceReferenceTracheotomyFacial rejuvenationLaparoscopic surgeryRefractive surgery

Georgia Health Sciences University surgeons developed the technique utilizing the remote access capabilities of robots, experience gained from another no-neck-scar approach through the armpit and earlier success removing the largest salivary gland from the lower jaw region.

"It is outpatient, it doesn't require a surgical drain and it has the advantage of no neck scar," said Dr. David Terris, Chairman of the GHSU Department of Otolaryngology-Head and Neck Surgery.

The goal was a no-neck-scar technique that's as safe as conventional thyroidectomy, which involves an incision at the base of the neck to gain immediate access to the thyroid, the surgeons report in The Laryngoscope. Two articles detail experiences developing the technique in human cadavers and using it on 14 patients.

"The overarching principle is customizing the surgery to the patient and their disease as opposed to one size fits all. Our advice to patients and surgeons is to do what works best for you," said the studies' corresponding author Terris, who lays out all options for his patients.

Surgery has been done through a multi-inch neck incision for more than 100 years on the thyroid, the endocrine gland just under the Adam's apple that controls the body's metabolic rate. In the last decade, Terris and others have pioneered minimally invasive approaches that can reduce the incision to less than an inch.

In 2004, Terris and colleagues published another Laryngoscope paper that indicated, at least in pigs, the armpit approach worked for avoiding neck scars altogether. While this approach is used selectively in other countries, reports have surfaced of serious side effects such as damage to the brachial plexus, the main nerve to the arm and hand; blood loss; and perforation of the esophagus. After using it on small number of patients, Terris envisioned a more direct, logical route. That's when he thought about his earlier success at removing the large salivary gland through a facelift incision in the hairline.

The daVinci Surgical System, in which surgeons sitting at a console maneuver through tight spaces and around corners, enables remote access, via the armpit or a facelift incision, Terris said. He makes a small incision in the scalp line, burrows under the skin, then moves under the muscle as he nears the thyroid. A retractor developed by Korean surgeons keeps the skin and muscle out of the way while the long, flexible arms and three- dimensional perspective provided by the robot enables removal of up to half of the two-sided thyroid gland. Patients with known cancers or large thyroids are not candidates for this approach but Terris said advances in robotic technology may soon enable surgeons to reach around to access both sides of the thyroid through a single incision.

He notes the hairline approach takes longer and, primarily because of increased time under anesthesia, costs more than minimally invasive surgeries. He's now done more than 30 cases, but greater patient numbers are needed to increase confidence in the safety and feasibility of the approach, he said.

Unlike minimally invasive approaches that are easier on thin patients, the facelift thyroidectomy is actually easier on heavier patients. A common, transient side effect of this approach is temporary, localized numbness because of surgical contact with the nerve that innervates skin in the region.

Problems with the thyroid gland tend to occur in women in their 30s, 40s and 50s. Growths or goiters can result in a hyperactive thyroid gland and jittery, sweaty patients who can't gain weight. Typically if there is a single growth, the surgeons take out that half of the gland, rule out cancer and that is the end of the problem. If it is cancer, the good news is the thyroid can be completely removed, cure rates are high and the gland's function can be replaced by a single, daily pill, Terris said. Known causes of thyroid cancer include radiation exposure.

GHSU's Drs. Michael Singer and Melanie Seybt are study co-authors.

Email or share this story: